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PUBLICATIONS

  1. hang H, Reilly MP. (2015): IRF2BP2: A new player at the crossroads of inflammation and lipid metabolism.. Circ Res. 117(8):656-8. PMID: 26405180
  2. Oldham WM, Clish CB, Yang Y, Loscalzo J. (2015): Hypoxia-mediated increases in L-2-hydroxyglutarate coordinate the metabolic response to reductive stress.. Cell Metab. 22(2):291-303. PMID: 26212716
  3. Menche J, Sharma A, Kitsak M, Ghiassian SD, Vidal M, Loscalzo J, Barabási AL. (2015): Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science. 347(6224):1257601. PMID: 25700523
  4. Yao L, Li Y, Ghosh S, Evans JA, Rzhetsky A. (2015): Health ROI as a measure of misalignment of biomedical needs and resources. Nat Biotechnol. 33(8):807-11. PMID: 26252133
  5. Zhang H, Xue C, Shah R, Bermingham K, Hinkle CC, Li W, Rodrigues A, Tabita-Martinez J, Millar JS, Cuchel M, Pashos EE, Liu Y, Yan R, Yang W, Gosai SJ, VanDorn D, Chou ST, Gregory BD, Morrisey EE, Li M, Rader DJ, Reilly MP. (2015): Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease. Circ Res.. 117(1):17-28. PMID: 25904599.
  6. Chen Q, Zhou XJ, Sun F. (2015): Finding genetic overlaps among diseases based on ranked gene lists. J Comput Biol. 22(2):111-23. PMID: 25684200.
  7. Li W, Gong K, Li Q, Alber F and Zhou XJ. (2015): Hi-Corrector: a fast, scalable and memory-efficient package for normalizing large-scale Hi-C data. Bioinformatics, 2015 Mar; 31(6):960-962. PMID: 25391400.
  8. Wang W, Zhou XJ, Liu Z, Sun F. (2015): Network tuned multiple rank aggregation and applications to gene ranking. BMC Bioinformatics, 2015; 16(Suppl 1):S6.
  9. Tseng YT, Li W, Chen C, Zhang S, Chen JJW, Zhou XJ, and Liu CC (2015). IIIDB: a database for isoform-isoform interactions and isoform network modules. BMC Genomics. 16(Suppl 2):S10.
  10. Zhou Y, He CH, Herzog EL, Peng X, Lee CM, Nguyen TH, Gulati M, Gochuico BR, Gahl WA, Slade ML, Lee CG, Elias JA. (2015): Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation. Am J Respir Crit Care Med.. 191(7):746-57. PMID:25629580
  11. Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA. (2015): Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease. J Clin Invest. 125(8):3178-92. PMID: 26121745
  12. Catalan MA, Kondo Y, Pena-Munzenmayer G, Jaramillo Y, Liu F, Crandall ED, Borok Z, Flodby UP, Shull GE, Melvin JE. (2015): A novel fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Nat Acad Sci (USA), 112(7):2263-2268. PMID: 25646474
  13. Bauer RC, Tohyama J, Cui J, Cheng L, Yang J, Zhang X, Ou K, Paschos GK, Zheng XL, Parmacek MS, Rader DJ, Reilly MP. (2015): Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice. Circulation. 131(13):1202-13. PMID: 25712206
  14. Rosas IO, Kaminski N. (2015): Update in diffuse parenchymal lung disease, 2013. Am J Respir Crit Care Med. 191(3):270-4. PMID:25635490
  15. Liu A, Cardell J, Ariel D, Lamendola C, Abbasi F, Kim SH, Holmes TH, Tomasso V, Mojaddidi H, Grove K, Kushida CA, Reaven GM. (2015): Abnormalities of lipoprotein concentrations in obstructive sleep apnea are related to insulin resistance. Sleep. 38(5):793-9. PMID: 25348129
  16. Sharma, A., Menche, J., Huang, C., Ort, T., Zhou, X., Kitsak, M., Sahni, N., Thibault, D., Voung, L., Guo, F., Gulbahce, N., Baribaud, F., Tocker, J., Dobrin, R., Barnathan, E., Liu, H., Panettieri, R.A., Jr., Tantisira, K.G., Qiu, W., Raby, B.A., Silverman, E.K., Vidal, M., Weiss, S.T., and Barabasi, A.-L. (2015):  A disease module in the interactome explains disease heterogeneity and drug response, and captures novel pathways and genesHum. Mol. Genet. e-published.
  17. Zhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL. (2014): Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis. Sci Transl Med. 6(240):240ra76. PMID: 24920662
  18. Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z. (2014): Claudin 4 knockout mice: normal physiologic phenotype with increased susceptibility to lung injury. Am J Physiol. 307:L524-L536. PMID: 25106430
  19. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. (2014): Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasisAm J Respir Cell Mol Biol. 51:210-222.
  20. Menche, J., Sharma, A., Kitsak, M., Ghiassian, S., Vidal, M., Loscalzo, J., and Barabasi, A.-L. (2015):  Uncovering disease-disease relationships through the human interactomeScience. 347:841.
  21. Wang, R.-S., Oldham, W., and Loscalzo, J. (2014):  Network-based association of hypoxia-responsive genes with cardiovascular diseasesNew J. Physics 16:105014.
  22. Hall, K., Nelson, C., Davis, R., Buring, J., Kirsch, I., Mittleman, M., Loscalzo, J., Samani, N., Ridker, P., Kaptchuk, T., and Chasman, D. (2014):  Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular diseaseArterio. Thromb. Vasc. Biol. 34:2160-2170.
  23. Chu, J.-H., Hersh, C.P., Castaldi, P.J., Cho, M.H., Raby, B.A., Laird, N., Bowler, R., Rennard, S., Loscalzo, J., Quakenbush, J., and Silverman, E.K. (2014):  Analyzing networks of phenotypes in complex diseases: methodology and applications in COPDBMC Syst. Biol. 8:78.
  24. Ridker, P.M., Chasman, D.I., Rose, L., Loscalzo, J., Elias, J.A. (2014):  Plasma levels of the proinflammatory chitin-binding glycoprotein YKO40, variation in the chitinase 3-like 1 (CHI3L1), and incident cardiovascular eventsJ. Am. Heart Assoc. 3:e000897.
  25. Jiang CR, Liu CC, Zhou XJ, Huang H. (2014) Optimal ranking in multi-label classification using local precision rates. Statistica Sinica. 24:1547-1570.
  26. Zhang S and Zhou XJ. (2014) Matrix factorization methods for integrative cancer genomics. Methods in Molecular Biology. 1176:229-42.
  27. Ridker PM, Chasman DI, Rose L, Loscalzo J, Elias JA. (2014) Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events. J Am Heart Assoc. 3:e000897. 
  28. Jafari B, Elias JA, Mohsenin V. (2014) Increased plasma YKL-40/Chitinase-3-Like-Protein-1 is associated with endothelial dysfunction in obstructive sleep apnea. PLoS One. 9(5):e98629. PMID: 24878721
  29. Rzhetsky A, Bagley SC, Wang K, Lyttle CS, Cook EH Jr, Altman RB, Gibbons RD. (2014) Environmental and state-level regulatory factors affect the incidence of autism and intellectual disability. PLoS Comput Biol. 10(3):e1003518. PMID: 24625521
  30. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. (2014)  Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Mar.
  31. Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary PM, Loscalzo J, Crandall E, Zhou XJ. (2014) DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res, 2014 June; DOI: 10.1093/nar/gku412. PMID: 24895436
  32. Zhou X, Menche J, Barabási AL, Sharma A. (2014) Human symptoms–disease network. Nat Comm. 26 Jun 2014. 
  33. Li W, Dai C, Kang S, Zhou XJ. (2014) Integrative analysis of many RNA-seq datasets to study alternative splicing. Methods 67(3):313-324. PMID: 24583115
  34. Reilly JP, Meyer NJ, Shashaty MGS, Feng R, Lanken PN, Gallop R, Kaplan S, Herlim M, Oz NL, Hiciano I, Campbell A, Holena D, Reilly MP, Christie JD. (2014) ABO blood type A is associated with increased risk of acute respiratory distress syndrome in Caucasians following both major trauma and severe sepsis. Chest. 2014 Jan. PMID: 24385226
  35. Loscalzo J. (2014) A celebration of failure. Circulation. 129(9):953-5. PMID: 24589694
  36. Menche J, Sharma A, Cho MS, Mayer RJ, Rennard SI, Celli B, Miller BE, Locantore N, Tal-Singer R, ghosh S, Larminie C, Bradley G, Riley JH, Agusti A, Silverman EK, Barabasi AL. (2014) Divisive shuffling approach (VIStA) for gene expression analysis to identify subtypes of chronic obstructive pulmonary disease. BMC Syst Biol. 8(Suppl 2):S8.
  37. Noth I, Kaminski N. (2013) Idiopathic pulmonary fibrosis: time to get personal?. Am J Respir Crit Care Med. 188(12):1392-4. PMID:24328772
  38. Yin T, Bader AR, Hou TK, Maron BA, Kao DD, Qian R, Kohane DS, Handy DE, Loscalzo J, Zhang YY. (2013) SDF-1α in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules 14(11):4009-4020. PMID: 24059347
  39. Schulz MH, Pandit KV, Lino Cardenas CL, Ambalavanan N, Kaminski N, Bar-Joseph Z. (2013) Reconstructing dynamic microRNA-regulated interaction networks. Proc Natl Acad Sci U S A. 110(39):15686-91. PMID: 23986498
  40. Herazo-Maya JD, Noth I, Duncan SR, Kim S, Ma SF, Tseng GC, Feingold E, Juan-Guardela BM, Richards TJ, Lussier Y, Huang Y, Vij R, Lindell KO, Xue J, Gibson KF, Shapiro SD, Garcia JG, Kaminski N. (2013) Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med. 5(205):205ra136. PMID: 24089408
  41. Barzel B, Barabási AL. (2013) Network link prediction by global silencing of indirect correlations. Nat Biotechnol. 31(8):720-5. PMID: 23851447
  42. Barzel B, Barabási AL. (2013) Universalilty in network dynamics. Nat Phys. 9:673-681.doi: 10.1038/nphys2741.
  43. Maron BA, Tang SS, Loscalzo J.  (2013)  S-Nitrosothiols and the S-nitrosoproteome of the cardiovascular systemAntiox. Redox Signal. 18(3):270-287. PMID: 22770551
  44. Maron BA, Opotowsky AR, Landzberg MJ, Loscalzo J, Waxman AB, Leopold JA (2013): Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur J Heart Fail. 15(3):277-283. PMID: 23111998
  45. Silverman EK, Loscalzo J. (2013) Developing new drug treatments in the era of network medicine. Clin Pharmacol Ther. 93(1):26-28. PMID: 23212105
  46. Joseph J, Loscalzo J. (2013) Selenistasis: epistatic effects of selenium on cardiovascular phenotype.  Nutrients. 5(2):340-58. PMID: 23434902
  47. Maron BA, Waxman AB, Opotowsky AR, Gillies H, Blair C, Aghamohammadzadeh R, Loscalzo J, Leopold JA. (2013): Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol. 112(5):720-725. PMID: 23751938 
  48. Loscalzo J. (2013) The identification of nitric oxide as endothelium-derived relaxing factor. Circ Res. 113(2):100-103. PMID: 23833290
  49. Nallamshetty S, Chan SY, Loscalzo J. (2013) Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic Biol Med. 64:20-30. PMID: 23712003
  50. Kao DD, Oldebeken SR, Rai A, Lubos E, Leopold JA, Loscalzo J, Handy DE. (2013) Tumor necrosis factor-alpha-mediated suppression of dual-specificity phosphatase 4:  crosstalk between NFkappaB and MAPK regulates endothelial cell survival.  Mol Cell Biochem. 382(1-2):153-162. PMID: 23812841
  51. Joseph J, Loscalzo J. (2013) Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Nutrients 5(8):3235-3256. PMID: 23955381
  52. Handy DE, Loscalzo J, Leopold JA. (2013) Systems analysis of oxidant stress in the vasculature. IUBMB Life 65(11):911-20. PMID: 24265198
  53. Handy DE, Loscalzo J. (2012) Redox regulation of mitochondrial function. Antioxid Redox Signal. 16(11):1323-1367. PMID: 22146081
  54. Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J. (2012): Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol. 52(3):753-760. PMID: 22227328
  55. Loscalzo J. (2012): Personalized cardiovascular medicine and drug development: time for a new paradigm. Circulation 125(4):638-645. PMID: 22294708
  56. Chan SY, White K, Loscalzo J. (2012): Deciphering the molecular basis of human cardiovascular disease through network biology. Curr Opin Cardiol 27(3):202-209. PMID: 22382498
  57. Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, Cottrill KA, Shaik RS, Waxman AB, Zhang YY, Maron BA, Hartner JC, Fujiwara Y, Orkin SH, Haley KJ, Barabási AL, Loscalzo J, Chan SY. (2012) MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation, 125(12):1520-1532. PMID: 22371328
  58. Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J (2012) Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest 42(8):900-913. PMID: 22435680
  59. Loscalzo J. (2012) Irreproducible experimental results: causes, (mis)interpretations, and consequences. Circulation.. 125(10):1211-4. PMID: 22412087
  60. Antman E, Weiss S, Loscalzo J. (2012) Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine. Wiley Interdiscip Rev Syst Biol Med. 4(4):367-383. PMID: 22581565
  61. Chan SY, Loscalzo J. (2012): The emerging paradigm of network medicine in the study of human disease. Circ Res. 111(3):359-374. PMID: 22821909
  62. White K, Loscalzo J, Chan SY. (2012) Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension. Pulm Circ 2(3):278-90. PMID: 23130098
  63. Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. (2012): Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation 126(8):963-974. PMID: 22787113
  64. Silverman EK, Loscalzo J. (2012) Network medicine approaches to the genetics of complex diseases. Discov Med. 14(75):143-152. PMID: 22935211
  65. Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S, Lebeche D, Hajjar RJ, Loscalzo J, Leopold JA. (2012) Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc 1(6):e003905. PMID: 23316327
  66. Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. (2012): Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res. 56(12):1812-1824. PMID: 23097236
  67. Liberman M, Johnson RC, Handy DE, Loscalzo J, Leopold JA. (2011) Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem Biophys Res Commun. 413(3):436-441. PMID: 21907184
  68. Zhao Y, Jin J, Hu Q, Zhou HM, Yi J, Yu Z, Xu L, Wang X, Yang Y, Loscalzo J. (2011) Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab. 14(4):555-566. PMID: 21982715
  69. Li W, Kang S, Liu CC, Zhang S, Shi Y, Liu Y, Zhou XJ. (2013) High-resolution functional annotation of human transcriptome: predicting isoform functions by a novel multiple instance-based label propagation method. Nucleic Acids Res. 2013 Dec; DOI: 10.1093/nar/gkt1362. PMID: 24369432
  70. Negoda A, Kim KJ, Crandall ED, Worden RM. (2013) Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers. Biochim Biophys Acta. 1828(9):2215-2222. PMID: 23747366.
  71. Blair DR, Lyttle CS, Mortensen JM, Bearden CF, Jensen AB, Khiabanian H, Melamed R, Rabadan R, Bernstam EV, Brunak S, Jensen LJ, Nicolae D, Shah NH, Grossman RL, Cox NJ, White KP, Rzhetsky A. (2013) A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk. Cell. 155(1):70-80. PMID: 24074861
  72. Ma X, Chen T, Sun F. (2013) Integrative approaches for predicting protein function and prioritizing genes for complex phenotypes using protein interaction networksBriefings in Bioinformatics
    2013 Jun 19 [Epub ahead of print]. PMID:
    23788799
  73. Chen Q and Sun F. (2013) A unified approach for allele frequency estimation, SNP detection and association studies based on pooled sequencing data using EM algorithmsBMC Genomics14(Suppl 1):S1. PMID: 23369070
  74. Liu A, Kushida CA, Reaven GM. (2013) Risk for obstructive sleep apnea in obese, nondiabetic adults varies with insulin resistance statusSleep Breath17(1):333-8. PMID:
    22481243
  75. Liu A, Kushida CA, Reaven GM. (2013) Habitual Shortened Sleep and Insulin Resistance: an Independent Relationship in Obese Individuals. Metabolism. 62(11):1553-6. PMID: 23849514
  76. Zhang H, Mooney C, Reilly MP. (2012) ABO Blood Groups and Cardiovascular DiseasesInternational Journal of Vascular Medicine. Hindawi Publishing Corporation. Article ID 641917.​
  77. He CH, Lee CG, Dela Cruz CS, Lee CM, Zhou Y, Ahangari F, Ma B, Herzog EL, Rosenberg SA, Li Y, Nour AM, Parikh CR, Schmidt I, Modis Y, Cantley L, Elias JA. (2013) Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2. Cell Rep. 4(4):830-841. PMID: 23972995
  78. Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. (2012) Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. Cell Host Microb. 12(1):34-46. PMID: 22817986
  79. Schmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR, Cantley LG. (2013) Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function. J Am Soc Nephrol. 24(2):309-319. PMID: 23291472
  80. Le HS, Bar-Joseph Z. (2011) Inferring Interaction Networks using the IBP applied to microRNA Target Prediction. In Proceedings of the Twenty-Fifth Annual Conference on Neural Information Processing Systems (NIPS), 2011.
  81. Herazo-Maya JD, Kaminski N. (2012) Personalized medicine: applying 'omics' to lung fibrosis. Biomark Med. 6(4):529-40. PMID: 22917154
  82. Ahmad F, Champion HC, Kaminski N. (2012) Toward systems biology of pulmonary hypertension. Circulation. 125(12):1477-9. PMID: 22371329
  83. Huang GT, Athanassiou C, Benos PV. (2011) mirConnX: condition-specific mRNA-microRNA network integrator. Nucleic Acids Res. 39(Web Server issue):W416-23. PMID: 21558324
  84. Coronnello C, Hartmaier R, Arora A, Huleihel L, Pandit KV, Bais AS, Butterworth M, Kaminski N, Stormo GD, Oesterreich S, Benos PV. (2012) Novel modeling of combinatorial miRNA targeting identifies SNP with potential role in bone density. PLoS Comput Biol. 8(12):e1002830. PMID: 23284279
  85. Rajkumar R, Sembrat JC, McDonough B, Seidman CE, Ahmad F. (2012) Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. BMC Med Genet. 13:21. PMID: 22458570
  86. Frazziano G, Champion HC, Pagano PJ. (2012) NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone. Am J Physiol Heart Circ Physiol. 302(11):H2166-77. PMID: 22427511
  87. Valdez-Jasso D, Simon MA, Champion HC, Sacks MS. (2012) A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium. J Physiol. 590(Pt 18):4571-84. PMID: 22848044
  88. Zhang Y, Kaminski N. (2012) Biomarkers in idiopathic pulmonary fibrosis. Curr Opin Pulm Med. 18(5):441-6. PMID: 22847105
  89. Le HS, Bar-Joseph Z. (2013) Integrating sequence, expression and interaction data to determine condition-specific miRNA regulation. Bioinformatics. 29(13):i89-i97. PMID: 23813013
  90. Kass DJ, Rattigan E, Kahloon R, Loh K, Yu L, Savir A, Markowski M, Saqi A, Rajkumar R, Ahmad F, Champion HC. (2012) Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents pulmonary hypertension in monocrotaline-injured rats. PLoS ONE. 7(4):e35388. PMID: 22509410
  91. Bauer EM, Shapiro R, Zheng H, Ahmad F, Ishizawar D, Comhair SA, Erzurum SC, Billiar TR, Bauer PM. (2012) High mobility group box-1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of toll-like receptor 4. Mol Med. 18:1509-18. PMID: 23269975
  92. George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA. (2013) Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 48(3):374-81. PMID: 23239493
  93. Raat NJ, Tabima DM, Specht PA, Tejero J, Champion HC, Kim-Shapiro D, Baust J, Mik EG, Hildesheim M, Stasch JP, Becker EM, Truebel H, Gladwin MT. (2013) Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction. Antioxid Redox Signal. 2013 Jul 9. PMID: 23697678
  94. Valdez-Jasso D, Simon MA, Champion HC, Sacks MS. (2012) A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium. J Physiol. 590(Pt 18):4571-84. PMID: 22848044
  95. Khoo NK, Cantu-Medellin N, Devlin JE, St Croix CM, Watkins SC, Fleming AM, Champion HC, Mason RP, Freeman BA, Kelley EE. (2012) Obesity-induced tissue free radical generation: an in vivo immuno-spin trapping study. Free Radic Biol Med. 52(11-12):2312-9. PMID: 22564528
  96. Cruz JA, Bauer EM, Rodriguez AI, Gangopadhyay A, Zeineh NS, Wang Y, Shiva S, Champion HC, Bauer PM. (2012) Chronic hypoxia induces right heart failure in caveolin-1-/- mice. Am J Physiol Heart Circ Physiol. 302(12):H2518-27. PMID: 22505641