The MAPGen Project identifies and characterizes common pathobiologic traits and/or mechanisms that cross organ systems and diseases with the ultimate goal of redefining heart, lung, blood, and sleep disorders based on newfound knowledge of the underlying molecular and/or cellular pathobiology.

This will provide the basis for the rational, mechanism-based development of new diagnostic, prognostic and therapeutic strategies for heart, lung, blood and sleep disorders. Measures that define phenotype by mechanism across a wide range of study populations will yield a more integrated understanding of pathobiology across pre-disease and disease states, recognition of subpopulations within heterogeneous diseases, more precise use of molecular target-direct therapies, and, ultimately, stronger associations with genetic variants than have typically been found using disease-related phenotypes. The ultimate goal of this project is to achieve effective, personalized medical care through more precise identification of populations that will benefit from mechanism-based interventions for prevention and treatment.

A database server, DiseaseConnect, has been developed to facilitate the analysis and visualization of a comprehensive knowledge on mechanism-based disease connectivity.

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